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2.4.1 The antagonistic roles of CHAC1 and CHAC2 in stem cell regulation The function of CHAC1 is further refined by its competitive interaction with its homolog, CHAC2

Glutathione may provide antioxidant support, enhance detoxification, bolster immune function, potentially support fetal development, and help reduce stress

2003 doi: 10.1016/S0140-6736(03)13413-7

The increased oxidative stress seems to be the second hit in the progression from NAFL to NASH: the increase in ROS and consequently in lipid peroxidation has been associated to hepatocellular damage, inflammation, and eventual fibrosis due to the activation of hepatic stellate cells